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KMID : 0191120180330260178
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Journal of Korean Medical Science
2018 Volume.33 No. 26 p.178 ~ p.178
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Plasma CRABP2 as a Novel Biomarker in Patients with Non-Small Cell Lung Cancer
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Kim Do-Jun
Kim Woo-Jin
Lim Myoung-Nam
Hong Yoon-Ki
Lee Seung-Joon
Hong Seok-Ho
Heo Jeong-Won
Lee Hui-Young
Han Seon-Sook
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Abstract
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Background: Lung cancer is the most common cause of cancer-related mortality worldwide. We previously reported the identification of a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung cancer tissues. The aim of this study was to assess plasma levels of CRABP2 from patients with non-small cell lung cancer (NSCLC).
Methods: Blood samples that were collected from 122 patients with NSCLC between September 2009 and September 2013 were selected for the analysis, along with samples from age- (± 5 years), sex-, and cigarette smoking history (± 10 pack-years [PY])-matched controls from the Korea Biobank Network. The control specimens were from patients who were without malignancies or pulmonary diseases. We measured plasma levels of CRABP2 using commercially available enzyme-linked immunosorbent assay kits.
Results: The mean age of the NSCLC patients was 71.8 ± 8.9 years, and the median cigarette smoking history was 32 PY (range, 0?150 PY). Plasma CRABP2 levels were significantly higher in patients with NSCLC than in the matched controls (37.63 ± 28.71 ng/mL vs. 24.09 ± 21.09 ng/mL, P < 0.001). Higher plasma CRABP2 levels were also correlated with lower survival rates in NSCLC patients (P = 0.014).
Conclusion: Plasma CRABP2 levels might be a novel diagnostic and prognostic marker in NSCLC.
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KEYWORD
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Carcinoma, Non-Small Cell Lung, CRABP2, Biological Marker
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